University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: robert.toto@utsouthwestern.edu. LMC Diabetes & Endocrinology, Thornhill, ON, Canada. Stanford University School of Medicine, Stanford, CA, USA. Bogier Clinical and IT Solutions, Raleigh, NC, USA. Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.